Understanding the Endocannabinoid System & Hemp

Healthful relationships play a large role in the quality of our everyday existence. From our family bonds, the environments in which we live, the food we eat, how we physically feel, to how we see ourselves. Certain connections are critical for balance to make it all work together. This is particularly true for our body, which has a life-essential regulatory system based on biochemical relationships that helps us maintain equilibrium, despite life’s up and downs. These connections comprise the Endocannabinoid System (ECS). Hemp has a unique and interactive lock and key relationship with ECS. 

Cannabinoid graphic
The ECS “Power Couple”

What exactly is ECS? Discovered in the 1990s, ECS is thought to be one of the most vital yet vast receptor systems for sustaining good health. ECS affects many biological processes in humans, in fact, it affects all vertebrate animals, as well as some invertebrates.

ECS contains cannabinoid receptors or “locks,” while the group of chemical compounds called cannabinoids, should be viewed like “keys.” The body produces various endogenous cannabinoids, most notably anandamide and 2-arachidonoylglycerol (2-AG) and are found in the immune system, the central nervous system, brain, various organs, connective tissue, and glands.

Since hemp contains elevated levels of Cannabidiol (CBD), active phytocannabinoids work in concert with other secondary phytocannabinoids and compounds (i.e. terpenes and flavonoids), and works well with the ECS in order to unlock the receptor locks. Think of hemp as the ‘key’ to the receptors.

The major function of the ECS is to maintain system homeostasis by providing a state of internal stability necessary for survival, despite fluctuations in the external environment. The ECS is also involved in many physiological processes like appetite, sleep, digestion, mood, memory, metabolism, neuro-protection, hormones, and heart function.

The ECS has a series of receptors in cells throughout the body that binds the cannabinoids found in hemp extract oil. Two main kinds of receptors are cannabinoid 1 (CB1) and cannabinoid 2 (CB2) and they receive three types of cannabinoids:

Endocannabinoids – Cannabinoids made in our body
Phytocannabinoids – Derived from natural plant cannabinoids
Synthetic Cannabinoids – Synthetically created

CB1 is mostly found in the brain, as well as in the lungs, kidney, liver, bones, heart, male and female reproductive organs. This receptor is more keyed into THC (tetrahydrocannabinol), the main cannabinoid in marijuana. CB2 however lives in the immune system, with a significant presence in the spleen as well as the lungs, liver, bone and muscle. Metabolic enzymes, FAAH and MAGL, are used by the ECS to accelerate chemical reactions and efficiently break down cannabinoids once they’ve served their purpose.

Understanding the relationship with the Endocannabinoid System and homeostasis is key. It’s essential as to how we thrive, heal and function for body and mind wellness. Through science additional answers will continue to reveal why our body is responsive to hemp and whole-plant cannabinoids as much still appears to be unknown.

Hope this introduction provides you with a better understanding how CBD works in the body. We offer only locally sourced, Certified Natural Grow CBD products from our supplier in 300 mg, 600 mg potency and are pleased to now offer a 1200 mg strength for those who need a stronger dosage. While the labels have changed, it’s still the same quality product and formulations we’ve carried since the shop went live. Check the K-9 store for product details and prices. Products are always shipped free when you place your order and are sent out ASAP (same day as ordered presuming the post office is open). Feel free to contact us with any specific questions.

Live, love, bark! 🐾

Catch Up Tuesday

Returning from a wonderful vacation, I’m more behind than ever so this week may not see a lot of blog action but don’t be alarmed if I don’t comment on your posts. The WiFi situation (along my international data plan) were inadequate to keep fully on top of things but rest assured, I will read every blog post that arrived in my inbox, even if I don’t leave a comment.

Suffice to say the trip was worth every sun-filled moment. What’s not to enjoy and love when there’s good company, good food, and good drinks? Oh, and a gorgeous view that will remain in my memory banks for a good long time.

On a less happy note, just a week shy of being six-months seizure free, Elsa had a small seizure last night. She’s fine and back to her normal self and resting right now. While I was gone, she apparently learned how to amp up the motor that controls her tail wag speed because when I walked in, I had never seen it wag so fast. It fills my heart with such joy to see this once shut-down precious Ninja expressing canine glee. In looking back over her seizure log last night, I noted this has been the longest period of time she hadn’t had an episode which I attribute it to the switching of CBD oil brands to Black Dog Botanicals (which can be found in the e-shop here in both canine and human strength). Her blood values will be screened sometime over the next couple of weeks and I should have a better sense of her progress then. The vet said if we could limit her to a couple a month, she’d be happy, so I’m sure this will merit some pawsitive note in Elsa’s medical file.

Sam, Elsa and I  send our very best Happy Thanksgiving greeting to you and yours. We’ll see you soon!

Live, love, bark!🐾

Changes

The weather isn’t the only thing changing around the Ranch. Our new e-shop is open. The intent was to post the news with a flourish of trumpets and angels singing.

The ‘shop’ Sam’s K9 Kreations is open. Sort of. That sound accompanying it isn’t so much trumpets, think more like a couple of out-of-tune kazoos. And the angels…I’m sure I heard the heavens snickering. *Sigh*

Earlier this week I created a simple “Pay Button” (courtesy of those nice folks at WordPress) and began beta testing to make sure it worked. It did in fact, but it became crystal clear that the blog needed to be upgraded to allow for customization which wasn’t possible to sell CBD oil along with other items. It looked and felt much like a kid’s cardboard lemonade stand. On the third weekend. So, I bit the bullet, upgraded the blog and with that upgrade began a crash course on customization in e-commerce. That sound you are hearing now is much like the sound of a plane dive-bombing into the ocean.

If you are familiar with the WooCommerce platform (or any other e-commerce tool), I bow down before you. The installation of plugins, reinstallation of photos and descriptions (plus other elements not seen but necessary to keep the wheels on) made conversion from the simple pay button page to WooCommerce one heck of a mind-sucking exercise. In my case it’s like a blind pilot is behind the steering wheel of that plane headed for the ocean.

After birthing this elephant sized cluster, it appears to be up and operational but there are issues with appearance that are affecting the blog (who knew there was so much behind the scenes online). As I become more proficient on the deets of e-commerce (please Gawd, let. me. become. proficient), you will likely see some changes to our blog header and the theme (which, lucky me…does not lend itself to supporting an e-storefront). There’ll be tinkering and consulting with professionals today, tomorrow and for many days in the future regarding the inner workings and appearance elements, so I apologize in advance if it messes up your internal brain-compass juju like it has mine. Changing the appearance affects me much like changes in the dogs’ routine. In other words, we kind of hobble around until we catch our stride.

Long story short, you can now purchase the Black Dog Botanicals CBD oil I’ve been touting lately (which comes in two strengths-300 mg and 600 mg. Other products (the handmade greeting cards like the ones posted on Instagram), pet accessories and organic treats will begin showing up as we move forward. In the meantime, pray for me. I’m simultaneously terrified and excited about this new endeavor. But understand I’m clearly no Jeff Bezos and this here shop ain’t no Amazon. If I haven’t scared you off yet, visit the “Sam’s K9 Kreations” page to the right of our “Home” page. Here’s hoping the news the angels begin singing a bit soon.

Live, love, bark! 🐾

The 411 on CBD

CBD is getting a whole lot of press these days and for good reason. From pain management to managing anxiety responses and a whole lot in between, CBD oil is making quite the name for itself with numerous opportunities for medical benefit. CBD is a natural way of regulating the body’s endocannabinoid system. So what is this CBD oil all about, you ask?

Cannabis sativa is a species of plant with well over 60 active agents called cannabinoids, the most well-known of which are THC and CBDTHC is the psychoactive ingredient found in marijuana, while CBD is non-psychoactiveCBD, derived from industrial hemp must contain less than 0.3% THC. Cannabinoid receptors are normally found throughout the body in both human and canine nervous systems, glands and organs and all mammals rely on the endocannabinoid system to regulate the immune response. Use of CBD is a natural way in regulating this system.

According to PetCareRx, 20% of all dogs will suffer from some developmental or degenerative joint pain during their lives. Whether it’s caused by genetics or age, joint pain will definitely reduce the their quality of life. Starting out as mild discomfort, it can progress to chronic pain. CBD can target receptors throughout the body and reduce any inflammation or nerve-related pain.

CBD is also an effective treatment for anxiety. Triggers like a trip to the vet, a thunderstorm, separation anxiety or phobias can be reduced when CBD is administered in advance. For the estimated 5% of dogs who suffer from epilepsy like Elsa, CBD in combination with vet prescribed anti-seizure medication, has allowed a reduction in her Phenobarbital dosage by 25%. CBD is known to have properties that block symptoms from taking over the brain and can potentially reduce the frequency and severity of seizures. Colorado State University is currently conducting a study that suggests 89% of dogs who received CBD had a reduction in frequency of seizures. Dr. Stephanie McGrath, overseeing clinical trials on the use of CBD treatment for epilepsy and osteoarthritis, presented her findings last month at the annual convention of the American Veterinary Medication Association. “This pilot study is important and it does seem like there is a positive effect from the use of CBD for dogs with epilepsy,” said Dr. McGrath. To learn more about the clinical trial, visit the hospital’s website.

Although much confusion exists, CBD oil derived from hemp is legal for purchase in all 50 states. Initial studies show CBD is safe for dogs and most veterinary professionals recommend starting with small doses as our vet recommended. We had to tinker with Elsa’s dosage and finally settled on 15 drops of 300 mg spread out throughout the day in conjunction with the vet’s recommendation. Since switching to Blackdog Botanicals, she has had only 2 seizures, both of which were extremely minor. Elsa’s vet is very pleased with her progress on CBD oil.

“CBD has been shown to decrease the production and release of inflammatory cytokines that can cause allergies, hypersensitivities and autoimmunity. It can also suppress something called Th17 dominance, which is a major cause of autoimmune diseases. CBD also inhibits the production of inflammatory macrophages and decreases chronic inflammation. CBD is also a powerful antioxidant that’s shown to be more powerful than vitamins C and E.” [Source: Dogs Naturally Magazine]

According to Wikipedia: “Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase (FAAH), which may then increase the levels of endocannabinoids, such as anandamide, produced by the body. Speculation suggested some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.”

As more and more vet professionals become aware of the benefits CBD provides pets, it stands to reason that more and more people are getting into the business of CBD oil,  which is quite lucrative. It’s imperative that owners be aware of the strength and efficacy of the product as not all products are created equal. In other words, make sure to do your homework and discuss CBD usage with your vet

Live, love, bark! 🐾